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Mutagenic activity of cyclophosphamide, ifosfamide, and ...
Experiments are performed to compare the mutagenic properties of the three phosphamide esters of nitrogen mustard, cyclophosphamide (CP), ifosfamide ...
www.springerlink.com/index/J48256470727V367.pdf
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Evaluation of Organ Specificity of Mutagenic Effects of ...
for evaluation of organ specificity of mutagens and for prediction of the carcinogenic effects of chemical compounds. Key Words: cyclophosphamide; mutagenic ...
www.springerlink.com/index/KMH3888640671U43.pdf
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Induction of micronuclei in metabolically competent rat ...
... and cyclophosphamide, as pro-mutagens and mitomycin C as a direct acting mutagen. ... United Kingdom Environmental Mutagen Society. Annual meeting No18, ...
cat.inist.fr/?aModele=afficheN&cpsidt=3396309
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In utero analysis of sister chromatid exchange: alterations in ...
Because cyclophosphamide is a metabolically activated mutagen, a direct-acting drug, mitomycin C, was given on days 11 and 15 to determine if the decline in ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid...
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Cytogenetic studies of sodium fluoride in mice.
Cyclophosphamide/pharmacology. Erythrocytes/drug effects ... Mutagens. Cyclophosphamide. Sodium Fluoride. PMID: 7837981 [PubMed - indexed for MEDLINE] ...
www.ncbi.nlm.nih.gov/pubmed/7837981?dopt=Abstract
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Cyclophosphamide (IARC Summary & Evaluation, Volume 26, 1981)
Cyclophosphamide demonstrated mutagenic activity in several different assays (bacteria, yeast and mammalian cells in vitro, and Drosophila and mice in vivo).
www.inchem.org/documents/iarc/vol26/cyclophosphami...
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Induction of mutant lymphocytes in cyclophosphamide- and ...
© 2001 UK Environmental Mutagen Society/Oxford University Press ... Copyright © 2009 United Kingdom Environmental Mutagen Society ...
mutage.oxfordjournals.org/cgi/content/full/16/3/19...
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The Hospital for Sick Children - Cyclophosphamide
Zemlickis et al: Teratogenicity and carcinogenicity in a twin exposed in utero to cyclophosphamide. Teratogenesis Carcinog Mutagen 13:139-43, 1993.
www.motherisk.org/prof/commonDetail.jsp?content_id...
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A comparison of mutagenic and snbryotoxic effects of ...
For the comparative analysis of mutagenic and embryotoxic effects we chose cyclophosphamide, a well-known mutagen [Ames et al, 1973; Benedict et al, 1978; ...
doi.wiley.com/10.1002/em.2860080206
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IARC Vol 26
Cyclophosphamide demonstrated mutagenic activity in several different assays (bacteria, yeast and mammalian cells in vitro, and Drosophila and mice in vivo).
monographs.iarc.fr/ENG/Monographs/vol26/volume26.p...
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Spectra of spontaneous and mutagen-induced mutations in the ...
... administered adriamycin and cyclophosphamide. Environ Mol Mutagen. ... Cyclophosphamide teratogenesis: a review. Teratog Carcinog Mutagen. 1985;5(2):7588. ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC52424/?tool=p...
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Mutagenic and teratogenic effects of cyclophosphamide on the chick ...
Cyclophosphamide is one of the most extensively studied mutagens and terato- gens. The mechanism of the mutagenic effect of CP is at present in principle ...
doi.wiley.com/10.1002/tcm.1770100407
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Bioline International Official Site (site up-dated regularly)
Cyclophosphamide, the standard mutagen used in this study produced significant decrease in PCE and P/N ration and significant increase in NCE, MPCE and MNCE (p 0.05).
www.bioline.org.br/request?pt06018
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Role of O6-Alkylguanine-DNA Alkyltransferase in Protecting against ...
Cyclophosphamide has been reported as a mutagen and carcinogen to humans. Evidence suggests that its mutagenic effects are associated with DNA adducts generated from both metabolites ...
cancerres.aacrjournals.org/cgi/content/full/59/13/...
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Effects of caffeine on sister-chromatid exchanges (SCE) in vivo.
Chinese hamsters were twice treated with caffeine via stomach tube. ... injections of the chemical mutagens, cyclophosphamide or benzo[a]pyrene, led ...
www.medscape.com/medline/abstract/108595
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Inhibition of genotoxic effects of mammalian germ cell mutagens ...
The most frequently studied mutagens were benzo[a]pyrene, cyclophosphamide, mitomycin C, and bleomycin. Based on the availability of the most relevant data, ...
linkinghub.elsevier.com/retrieve/pii/S002751079700...
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ISPUB - Protective action of EGCG against anticancer drugs ...
... drugs, Methyl methanesulphonate (MMS) and cyclophosphamide (CP), in the ... and cyclophosphamide (known mutagens), both in the presence and absence of ...
www.ispub.com/journal/the_internet_journal_of_phar...
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Detection of cyclophosphamide-induced mutations at...[Environ Mol
Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacI transgenic mice. [Environ Mol Mutagen. 1999]
www.ncbi.nlm.nih.gov/pubmed/10529741
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Relative Mutagenicity of Some Urinary Metabolites of the Antitumor ...
Of the four compounds tested, NM was the strongest mutagen while all the others had ... in high levels in the urine of cyclophosphamide-treated patients. ...
cancerres.aacrjournals.org/cgi/content/abstract/41...
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